Feasibility of optical quality analysis system for the objetctive assessment of accommodation insufficiency: a phase 1 study



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López Artero, Esther and Garzón Jiménez, Nuria and Rodríguez Vallejo, Manuel and García Montero, María (2020) Feasibility of optical quality analysis system for the objetctive assessment of accommodation insufficiency: a phase 1 study. Journal of Optometry . 8 p.. ISSN 1888-4296 (In Press)

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Official URL: https://doi.org/10.1016/j.optom.2020.06.004


Purpose: To assess differences in a new objective metric obtained with a double-pass technique between a group with accommodation insufficiency (AI) and a control group and to explore the diagnostic capabilities of this new tool in comparison to conventional procedures.
Methods: Retrospective cross-sectional case-control phase 1 study. Two groups age ranging from 8 to 18 years were recruitment: AI and control group. The diagnostic criterion of AI was based on monocular accommodative amplitude (AA) 2 D below Hofstetter’s calculation for minimum AA and monocular accommodative facility (MAF) failing with minus lens and cut-off at ≤ 6 cycles per minute. Accommodative response with a double pass device (HD Analyzer, Visiometrics) was measured, performing an evaluation from +1.00 D to −3.50D (−0.5D steps), offering the width of the profile at 50% (WP) in minutes of arc.
Results: Differences were found between groups for the AA, MAF and MEM retinoscopy (p < 0.0001, p < 0.001, p = 0.037). The discriminative capacity of MEM retinoscopy for AI diagnosis was significant and the cut-off that maximized the sensitivity and specificity was > 0.5 D. Considering WP 50% in different points, the discriminative AI diagnosis capacities for the points of 2.0 D and 2.50 D were significant (ROC-AUC 0.78; p = 0.03 and p = 0.02).
Conclusions: Double-pass system metric differed between patients with AI and control group, therefore the aim of a Phase I study was achieved. Further steps with higher sample sizes are required to evidence if the system really provides any advantage versus conventional methods in the diagnosis of AI.

Item Type:Article
Additional Information:

Recibido: 11 enero 2020; Aceptado: 29 junio 2020

Uncontrolled Keywords:Accommodation insufficiency; Amplitude accommodation; Doble-Pass
Subjects:Medical sciences > Optics > Optometry
Medical sciences > Optics > Geometrical and instumental optics
ID Code:61679
Deposited On:24 Aug 2020 18:09
Last Modified:24 Aug 2020 18:09

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