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Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

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Cañadas Benito, Olga and Olmeda Lozano, Bárbara and Alonso Eugenio, Alejandro and Pérez-Gil, Jesús (2020) Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis. International Journal of Molecular Sciences, 21 (10). pp. 1-39. ISSN 1661-6596, ESSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms21103708




Abstract

Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid–protein and protein–protein interactions contribute to the proper maintenance of an operative respiratory surface.


Item Type:Article
Uncontrolled Keywords:Ppulmonary surfactant film; Surfactant metabolism; Surface tension; Respiratory air–liquid; interface Inflammation; Aantimicrobial activity; Apoptosis; Efferocytosis; Tissue repair
Subjects:Medical sciences > Biology > Biochemistry
ID Code:62041
Deposited On:09 Sep 2020 10:22
Last Modified:02 Mar 2021 12:47

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