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Ruiz-Roso Guerra, María Belén and Echeverry Alzate, Víctor and Ruiz-Roso Calvo de la Mora, Baltasar and Quintela, José and Ballesteros Rodrigálvarez, Sandra and Lahera Julia, Vicente and Heras Jiménez, Natalia de las and López Moreno, José Antonio and Martín Fernández, Beatriz (2018) Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model. Nutrients, 11 (1). p. 11. ISSN 2072-6643
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Official URL: https://doi.org/10.3390/nu11010011
Abstract
Alzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown inconsistent results. Previously, we reported that the presence of phytanic acid (PhA) in standard DHA compositions could be blunting DHA’s beneficial effects. Therefore, we aimed to analyze the effects of a low PhA-concentrated DHA and a standard PhA-concentrated DHA in Apolipoprotein E knockout (ApoE
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alzheimer’s; DHA; ApoE -/- ; phytanic acid; inflammation; neuroprotection; oxidation |
| Subjects: | Medical sciences > Medicine > Neurosciences |
| ID Code: | 62162 |
| Deposited On: | 16 Sep 2020 11:25 |
| Last Modified: | 16 Sep 2020 11:25 |
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