Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model

Downloads

Downloads per month over past year

62162

Impacto

Downloads

Downloads per month over past year

Ruiz-Roso Guerra, María Belén and Echeverry Alzate, Víctor and Ruiz-Roso Calvo de la Mora, Baltasar and Quintela, José and Ballesteros Rodrigálvarez, Sandra and Lahera Julia, Vicente and Heras Jiménez, Natalia de las and López Moreno, José Antonio and Martín Fernández, Beatriz (2018) Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model. Nutrients, 11 (1). p. 11. ISSN 2072-6643

[thumbnail of nutrients-11-00011-v2.pdf]
Preview
PDF
Creative Commons Attribution.

4MB

Official URL: https://doi.org/10.3390/nu11010011




Abstract

Alzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown inconsistent results. Previously, we reported that the presence of phytanic acid (PhA) in standard DHA compositions could be blunting DHA’s beneficial effects. Therefore, we aimed to analyze the effects of a low PhA-concentrated DHA and a standard PhA-concentrated DHA in Apolipoprotein E knockout (ApoE


Item Type:Article
Uncontrolled Keywords:Alzheimer’s; DHA; ApoE -/- ; phytanic acid; inflammation; neuroprotection; oxidation
Subjects:Medical sciences > Medicine > Neurosciences
ID Code:62162
Deposited On:16 Sep 2020 11:25
Last Modified:16 Sep 2020 11:25

Origin of downloads

Repository Staff Only: item control page