Distinct Expression and Clinical Significance of Zinc Finger AN-1-Type Containing 4 in Oral Squamous Cell Carcinomas


Downloads per month over past year




Downloads per month over past year

Suárez-Canto, Julián and Suárez-Sánchez, Faustino and Domínguez-Iglesias, Francisco and Hernández Vallejo, Gonzalo and García Pedrero, Juana and de Vicente, Juan (2018) Distinct Expression and Clinical Significance of Zinc Finger AN-1-Type Containing 4 in Oral Squamous Cell Carcinomas. Journal of Clinical Medicine, 7 (12). p. 534. ISSN 2077-0383

[thumbnail of jcm-07-00534-v2.pdf]
Creative Commons Attribution.


Official URL: https://doi.org/10.3390/jcm7120534


Zinc finger AN1-type containing 4 (ZFAND4) has emerged as a promising prognostic marker and predictor of metastasis for patients with oral squamous cell carcinoma (OSCC). However, further validation is fundamental before clinical implementation. Hence, this study evaluated the expression pattern of ZFAND4 protein expression by immunohistochemistry using an independent cohort of 125 patients with OSCC, and correlations with the clinicopathologic parameters and disease outcome. Remarkably, ZFAND4 expression, while negligible in normal epithelium, exhibited two distinct expression patterns in tumors that did not overlap. A gross granular staining was characteristic of the undifferentiated cells at the invasive front of tumors, whereas the most differentiated cells located at the center of the tumor nests showed diffuse non-granular staining. ZFAND4 staining was higher in undifferentiated than in differentiated areas of tumors. High ZFAND4 expression in differentiated cells was significantly associated to well-differentiated (p = 0.04) and non-recurrent tumors (p = 0.04), whereas ZFAND4 expression in undifferentiated cells correlated with tumor location (p = 0.005). No correlations between the ZFAND4 expression and patient survival were found. These data question the clinical relevance of ZFAND4 expression as a prognostic biomarker in OSCC, and also reveal distinct ZFAND4 expression patterns depending on the differentiation areas of tumors that should be evaluated separately.

Item Type:Article
Uncontrolled Keywords:ZFAND4; ANUBL1; oral squamous cell carcinoma; immunohistochemistry; prognosis
Subjects:Medical sciences > Medicine > Oncology
Medical sciences > Dentistry
ID Code:62445
Deposited On:13 Oct 2020 14:09
Last Modified:13 Oct 2020 14:09

Origin of downloads

Repository Staff Only: item control page