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Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs

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Vera González, Vicente and Moran, Jose and Barros, Patricia and Canal-Macias, Maria and Guerrero-Bonmatty, Rafael and Costa-Fernandez, Carmen and Lavado-Garcia, Jesus and Roncero-Martin, Raul and Pedrera-Zamorano, Juan (2015) Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs. Nutrients, 7 (12). pp. 9908-9917. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu7125517




Abstract

We aimed to investigate and compare the effects of chronic antiepileptic therapy on bone health in pediatric patients using quantitative ultrasound of the phalanges (QUS) and controlling for potential confounding factors, particularly nutrient intake. The amplitude-dependent speed of sound (Ad-SoS) was measured in 33 epileptic children and 32 healthy children aged 6.5 ˘ 3.1 and 6.3 ˘ 1.1 (mean ˘ SD) years, respectively. There were no significant differences in the demographics such as age, weight and height between epileptic children and the control group children. None of the children in the epileptic or the treatment group were found to have a vitamin D deficiency. There were no significant differences in laboratory tests between groups. Lower QUS figures were found in the epileptic children (p = 0.001). After further adjustment for potential confounders such age, height, weight, calcium intake, vitamin D intake, physical activity and sex, the differences remained significant (p < 0.001). After further classification of the participants based on the tertile of calcium intake, no significant differences were found between patients and healthy controls in the greatest tertile of calcium intake (p = 0.217). We conclude that anticonvulsant therapy using valproate may lead to low bone mass in children and that an adequate intake of calcium might counteract such deleterious effects.


Item Type:Article
Uncontrolled Keywords:Antiepileptic therapy; bone health; quantitative ultrasound; children
Subjects:Medical sciences > Medicine > Pediatrics
Medical sciences > Medicine > Musculoskeletal System
ID Code:62446
Deposited On:07 Oct 2020 15:09
Last Modified:07 Oct 2020 15:09

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