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Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice

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Maldonado Bautista, Estela and López-Gordillo, Yamila and Partearroyo, Teresa and Varela Moreiras, Gregorio and Martínez Álvarez, Concepción and Pérez Miguelsanz, Juliana (2017) Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice. Nutrients, 10 (1). p. 26. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu10010026




Abstract

It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet.
Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes.


Item Type:Article
Uncontrolled Keywords:Tongue development; head development; congenital abnormalities; aglossia; microglossia; maternal folic acid-deficient diet; C57 mouse
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Gynecology and Obstetrics
ID Code:62447
Deposited On:07 Oct 2020 15:01
Last Modified:07 Oct 2020 15:01

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