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Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicine

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Baeza, Alejandro and Vallet Regí, María (2020) Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicine. Pharmaceutics, 12 (10). p. 957. ISSN 1999-4923

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Official URL: https://doi.org/10.3390/pharmaceutics12100957




Abstract

Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.


Item Type:Article
Additional Information:

RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-2026-6266 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:nanomedicine; mesoporous silica nanoparticles; theranostics; antitumoral therapy.
Subjects:Sciences > Chemistry > Materials
ID Code:62508
Deposited On:13 Oct 2020 14:20
Last Modified:13 Oct 2020 14:20

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