Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients



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Burgos Blasco, Bárbara and Güemes Villahoz, Noemi and Santiago García, José Antonio and Santiago, José Luis and Fernández Vigo, José Ignacio and Espino Paisán, Laura and Sarriá Ruíz, Beatriz Irene and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2020) Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients. Experimental Eye Research, 200 . ISSN 0014-4835

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Official URL: https://doi.org/10.1016/j.exer.2020.108253


The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed: interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF).
In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.

Item Type:Article
Additional Information:

Received 29 July 2020, Revised 30 August 2020, Accepted 14 September 2020, Available online 16 September 2020

Uncontrolled Keywords:Cytokine; COVID ; Tear ; Inflammation
Subjects:Medical sciences > Medicine > Communicable diseases
Medical sciences > Medicine > Ophtalmology
ID Code:62711
Deposited On:23 Nov 2020 08:52
Last Modified:23 Nov 2020 09:14

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