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Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis

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Montalvo Quirós, Sandra and Gómez Graña, Sergio and Vallet Regí, María and Prados Rosales, Rafael and González Ortiz, Blanca and Luque García, José Luis (2020) Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis. Colloids and Surfaces B: Biointerfaces . ISSN 0927-7765 (In Press)

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Official URL: https://doi.org/10.1016/j.colsurfb.2020.111405




Abstract

Tuberculosis remains today a major public health issue with a total of 9 million new cases and 2 million deaths annually. The lack of an effective vaccine and the increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics, anticipate a complicated scenario in the near future. The use of nanoparticles features as an alternative to antibiotics in tackling this problem due to their potential effectiveness in resistant bacterial strains. In this context, silver nanoparticles have demonstrated high bactericidal efficacy,although their use is limited by their relatively high toxicity, which calls for the design of nanocarriers that allow silver based nanoparticles to be safely delivered to the target cells or tissues.
In this work mesoporous silica nanoparticles are used as carriers of silver based nanoparticles as antimycobacterial agent against Mtb. Two different synthetic approaches have been used to afford, on the one hand, a 2D hexagonal mesoporous silica nanosystem which contains silver bromide nanoparticles distributed all through the silica network and, on the other hand, a core@shell nanosystem with metallic silver nanoparticles as core and mesoporous silica shell in a radial mesoporous rearrangement. Both materials have demonstrated good antimycobacterial capacity in in vitro test using Mtb, being lower the minimum inhibitory concentration for the nanosystem which contains silver bromide. Therefore, the interaction of this material with the mycobacterial cell has been studied by cryo-electron microscopy, establishing a direct connection between the antimycobactericidal effect observed and the damage induced in the cell envelope.


Item Type:Article
Additional Information:

RESEARCH ID N-4501-2014  (Sandra Sánchez Salcedo)
ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)
RESEARCHER ID G-7562-2016 (Sergio Gómez Graña)
ORCID 0000-0002-7736-051X (Sergio Gómez Graña)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID K-4773-2015 (Blanca González Ortiz)
ORCID 0000-0002-0493-6071 (Blanca González Ortiz)

Uncontrolled Keywords:antimycobacterial agents, Mycobacterium tuberculosis, tuberculosis, silver nanoparticles, mesoporous silica nanoparticles, bacteria wall disruption.
Subjects:Sciences > Chemistry > Materials
ID Code:62778
Deposited On:05 Nov 2020 11:46
Last Modified:05 Nov 2020 11:46

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