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Emerging strategies in anticancer combination therapy employing silica-based nanosystems.



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Castillo Romero, Rafael and Vallet Regí, María (2020) Emerging strategies in anticancer combination therapy employing silica-based nanosystems. Biotechnology Journal . ISSN 1860-7314 (In Press)

[thumbnail of 10.1002@biot.2019.pdf]

Official URL: https://doi.org/10.1002/biot.201900438


Combination therapy has emerged as one of the most promising approaches for cancer treatment. However, beyond remotely-triggered therapies that require advanced infrastructures and optimization, new combination therapies based on internally triggered cellkilling effects have also demonstrated promising therapeutic profiles. In this revision, we focus on self-triggered strategies able to improve the therapeutic effect of drug delivery nanosystems. As reviewed, ferroptosis, hypoxia, and immunotherapy show potency enough to treat satisfactorily tumors in vivo. However, the interest of combining those with chemotherapeutics, especially with carriers based on mesoporous silica, has provided a new generation of therapeutic nanomedicines with potential enough to achieve complete tumor remission in murine models.

Item Type:Article
Additional Information:

RESEARCH ID L-2854-2014  (Rafael Castillo Romero)
ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Combination therapy, Ferroptosis, Hypoxia, Immunotherapy, Mesoporous silica nanoparticles.
Subjects:Sciences > Chemistry > Materials
ID Code:62780
Deposited On:05 Nov 2020 11:36
Last Modified:14 Jan 2022 12:25

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