Publication: Papel de linfocitos γδ en helmintosis parasitarias
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2018-02
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Abstract
Los linfocitos Tγδ son un tipo de linfocitos T cuya característica principal es la capacidad de respuesta amplia y rápida (debido a que no necesitan procesamiento antigénico), por lo que se les atribuye un papel fundamental en la inmunidad innata o inespecífica. Durante la inflamación infecciosa estos linfocitos se convierten en efectores y reguladores ejerciendo su papel inmunoprotector y reparando el tejido asociado. Se ha estudiado su papel en helmintosis parasitarias, observándose que, aunque no haya una clara relación entre el papel protector de estos linfocitos Tγδ y todas las helmintosis parasitarias, sí se puede afirmar que en muchas de ellas tienen un papel fundamental en la expulsión de larvas y gusanos y que en muchas ocasiones la acción de los linfocitos Tγδ precede a la activación de los αβ (los linfocitos T más conocidos).
Además, las células T reguladoras, en las cuales se engloban estos linfocitos, pueden estar implicadas en el desarrollo de tumores, enfermedades autoinmunes e infecciosas, aunque no en la cronicidad de las mismas.
γδT cells are a kind of T cells whose main characteristic, is their wide and fast (since they don´t need antigen processing) answer capacity, and that is why they have this important role in non-specific immunity. During infectious inflammation these cells have effective and regulating functions and they play their protective role and they can even repair damaged tissue. Their function is widely studied in infections caused by helminthes. And, even though there is no clear relation between its protective role and all these parasites infections, it can be stated that in a lot of these infections γδT cells have a fundamental role in worm expulsion and in a lot of cases the action of these cells precede the action of αβT cells (the most known ones). In addition, T cells, which γδT cells belong to, can be related with tumor development and autoimmune and infectious diseases, even though they cannot be related with these diseases´chronicity.
γδT cells are a kind of T cells whose main characteristic, is their wide and fast (since they don´t need antigen processing) answer capacity, and that is why they have this important role in non-specific immunity. During infectious inflammation these cells have effective and regulating functions and they play their protective role and they can even repair damaged tissue. Their function is widely studied in infections caused by helminthes. And, even though there is no clear relation between its protective role and all these parasites infections, it can be stated that in a lot of these infections γδT cells have a fundamental role in worm expulsion and in a lot of cases the action of these cells precede the action of αβT cells (the most known ones). In addition, T cells, which γδT cells belong to, can be related with tumor development and autoimmune and infectious diseases, even though they cannot be related with these diseases´chronicity.