Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality



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González-Nieto, Daniel and Fernández-García, Laura and Pérez-Rigueiro, José and Guinea, Gustavo and Panetsos, Fivos (2018) Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality. Polymers, 10 (2). p. 184. ISSN 2073-4360

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Official URL: https://doi.org/10.3390/polym10020184


The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as well as their capacity to produce and deliver neuroprotective and neuroregenerative factors in the host tissue. Along this article, we review past and current trends in experimental and translational research to understand the opportunities, benefits, and types of tentative hydrogel-based applications for the treatment of cerebral disorders. Although the use of hydrogels for brain disorders has been restricted to the experimental area, the current level of knowledge anticipates an intense development of this field to reach clinics in forthcoming years.

Item Type:Article
Uncontrolled Keywords:Biomaterials; hydrogels; stem cells; stroke; brain repair
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Biology > Biotechnology
Medical sciences > Biology > Biochemistry
ID Code:62949
Deposited On:04 Nov 2020 15:25
Last Modified:04 Nov 2020 15:25

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