Differences between Inferior and Superior Bulbar Conjunctiva Goblet Cells in Scleral Lens Wearers: A Pilot Study

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Macedo de Araújo, Rute Juliana and Serramito Blanco, María and van der Worp, Eef and Carracedo Rodríguez, Juan Gonzalo and González Méijome, José Manuel (2020) Differences between Inferior and Superior Bulbar Conjunctiva Goblet Cells in Scleral Lens Wearers: A Pilot Study. Optometry and Vision Science, 97 (9). pp. 726-731. ISSN 1040-5488

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Official URL: http://dx.doi.org/10.1097/OPX.0000000000001575




Abstract

SIGNIFICANCE: Scleral lenses (SLs) rest on the scleroconjunctival region, which could result in a mechanical impact in the bulbar conjunctiva that can hypothetically modify some properties of conjunctival cells.
PURPOSE: The purpose of this study was to evaluate the differences in goblet cell density (GCD) and mucin cloud amplitude (MCA) between superior and inferior bulbar conjunctiva in SL wearers.
METHODS: A total of 26 eyes wearing SL were randomly selected from 26 subjects (11 females) with different grades of keratoconus enrolled in a prospective clinical series. Superior and inferior conjunctival impression cytologies were performed and therefore analyzed with scanning laser confocal microscopy to evaluate GCD and MCA. All subjects filled out the Ocular Surface Disease Index (OSDI) questionnaire.
RESULTS: The mean ± standard deviation OSDI score was 23.62 ± 15.12. Although a higher density of goblet cells was observed in the samples taken in the superior conjunctiva (74.70 ± 57.55 cells/mm2) than on the inferior conjunctiva (55.91 ± 34.80 cells/mm2), there were no statistically significant differences between them (P = .14, Wilcoxon). Regarding MCA, no differences were found between superior (21.81 ± 3.30 μm) and inferior (20.72 ± 2.95 μm) samples (P = .201, Wilcoxon). No statistically significant differences were found in GCD and MCA regarding the time of SL wear.
CONCLUSIONS: There were no differences in GCD and MCA in the samples taken in the superior and inferior conjunctival areas. Also, it seems that the SL wearing time does not affect the density and secretion of goblet cells. Prospective studies need to be conducted in larger samples to confirm those outcomes.


Item Type:Article
Additional Information:

Submitted: November 18, 2019;
Accepted: July 14, 2020

Uncontrolled Keywords:Bulbar conjunctiva; Cell density; Scleral lens; Conjunctival cells; MEchanical impact
Subjects:Medical sciences > Medicine > Surgery
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Optical materials
ID Code:62960
Deposited On:18 Feb 2021 14:00
Last Modified:19 Feb 2021 09:09

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