Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.

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Colilla Nieto, Montserrat and Vallet Regí, María (2020) Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment. International Journal of Molecular Sciences, 21 (22). p. 8605. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms21228605




Abstract

The rise of antibiotic resistance and the growing number of biofilm-related infectionsmake bacterial infections a serious threat f or global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infectiontargeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs
aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.


Item Type:Article
Additional Information:

RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica nanoparticles; bacterial infection; bacterial resistance; biofilm; targeting; antimicrobials; stimuli-responsive drug delivery.
Subjects:Sciences > Chemistry > Materials
ID Code:63100
Deposited On:17 Nov 2020 10:29
Last Modified:17 Nov 2020 10:29

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