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Incorporating Cellular Stochasticity in Solid–Fluid Mixture Biofilm Models

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Carpio, Ana and Cebrián, Elena (2020) Incorporating Cellular Stochasticity in Solid–Fluid Mixture Biofilm Models. Entropy, 22 (2). p. 188. ISSN 1099-4300

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Official URL: https://doi.org/10.3390/e22020188




Abstract

The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses, which determine the overall evolution. Incorporating stochastic cellular behavior in macroscopic models of biological media is a challenging task. Herein, we propose hybrid models for bacterial biofilm growth, which couple a two phase solid/fluid mixture description of mechanical and chemical fields with a dynamic energy budget-based cellular automata treatment of bacterial activity. Thin film and plate approximations for the relevant interfaces allow us to obtain numerical solutions exhibiting behaviors observed in experiments, such as accelerated spread due to water intake from the environment, wrinkle formation, undulated contour development, and the appearance of inhomogeneous distributions of differentiated bacteria performing varied tasks.


Item Type:Article
Uncontrolled Keywords:Biofilm; Cellular activity; Solid–fluid mixture; Thin film; Von Karman plate; Dynamic energy budget; Osmotic spread; Wrinkle formation; Cell differentiation
Palabras clave (otros idiomas):Biofilmes; Diferenciación celular; Ecuación de Von Karman
Subjects:Sciences > Computer science > Bioinformatics
Sciences > Mathematics
ID Code:63187
Deposited On:27 Nov 2020 12:30
Last Modified:30 Nov 2020 11:18

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