Publication: Corneal Properties in Primary Open Angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry
Loading...
Official URL
Full text at PDC
Publication Date
2020-12-10
Authors
Molero Senosiain, Mercedes
Morales Fernández, Laura
Sáenz Francés, Federico
Perucho González, Lucía
García Bella, Javier
Martínez de la Casa, Jose Maria
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Health
Citations
Exportar
Abstract
Purpose: To compare corneal topography and densitometry measurements in patients with primary open angle glaucoma (POAG) and healthy subjects.
Patients and Methods: 200 eyes of 75 patients with POAG and 125 healthy controls underwent corneal topography and densitometry (Oculus Pentacam HR). The data compared in the two groups were: anterior chamber angle (ACA), depth (ACD) and volume (ACV), keratometry (K minimum, K maximum and K mean), central corneal thickness (CCT), central anterior elevation (CAE), anterior elevation apex (AEA), maximum anterior elevation (MAE) and posterior elevation apex (PEA). Densitometry measurements were made at three depths on a 12▒mm-diameter circle divided into 4 concentric rings (0-2▒mm, 2-6▒mm, 6-10▒mm and 10-12▒mm). The diagnostic capacity of the corneal variables was assessed through the areas under the receiver operator characteristics (ROC) curve (AUC).
Results: The corneal density of practically all depth layers and total corneal density were significantly higher in the POAG than control group (P<0.05). Total corneal density was positively correlated with age (r=0.623; P<0.001) and also showed a good diagnostic capacity for glaucoma (AUC=0.617; IC 95% [0.541-0.697]; P<0.001). In a multiple linear regression designed to assess its relationship with age, gender, CCT and Km, age emerged as a significant confounder both in controls (coef. 0.315; P<0.001; 95% CI [0.246-0.384]) and patients (coef. 0.370; P<0.001; 95% CI [0.255-0.486]).
Conclusion: Corneal densitometry measurements showed a good diagnostic capacity for POAG suggesting this type of examination could have clinical applications in the diagnosis and management of glaucoma.