Corneal Properties in Primary Open Angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry



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Molero Senosiain, Mercedes and Morales Fernández, Laura and Sáenz Francés, Federico and Perucho González, Lucía and García Bella, Javier and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2020) Corneal Properties in Primary Open Angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry. Journal of Glaucoma . ISSN 1057-0829, 1536-481X (In Press)

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Purpose: To compare corneal topography and densitometry measurements in patients with primary open angle glaucoma (POAG) and healthy subjects.
Patients and Methods: 200 eyes of 75 patients with POAG and 125 healthy controls underwent corneal topography and densitometry (Oculus Pentacam HR). The data compared in the two groups were: anterior chamber angle (ACA), depth (ACD) and volume (ACV), keratometry (K minimum, K maximum and K mean), central corneal thickness (CCT), central anterior elevation (CAE), anterior elevation apex (AEA), maximum anterior elevation (MAE) and posterior elevation apex (PEA). Densitometry measurements were made at three depths on a 12▒mm-diameter circle divided into 4 concentric rings (0-2▒mm, 2-6▒mm, 6-10▒mm and 10-12▒mm). The diagnostic capacity of the corneal variables was assessed through the areas under the receiver operator characteristics (ROC) curve (AUC).
Results: The corneal density of practically all depth layers and total corneal density were significantly higher in the POAG than control group (P<0.05). Total corneal density was positively correlated with age (r=0.623; P<0.001) and also showed a good diagnostic capacity for glaucoma (AUC=0.617; IC 95% [0.541-0.697]; P<0.001). In a multiple linear regression designed to assess its relationship with age, gender, CCT and Km, age emerged as a significant confounder both in controls (coef. 0.315; P<0.001; 95% CI [0.246-0.384]) and patients (coef. 0.370; P<0.001; 95% CI [0.255-0.486]).
Conclusion: Corneal densitometry measurements showed a good diagnostic capacity for POAG suggesting this type of examination could have clinical applications in the diagnosis and management of glaucoma.

Item Type:Article
Uncontrolled Keywords:Corneal densitometry; PRimary open angle glaucoma; Corneal topography; Scheimpflug
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:63826
Deposited On:05 Mar 2021 09:13
Last Modified:10 Dec 2021 23:00

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