The Role of Autophagy in Eye Diseases

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Fernández Arrabal, José A. and Julián López, Esther, de and Soler Domínguez, Carmen and Hoz Montañana, María Rosa de and López Cuenca, Inés and García Martín, Elena Salobrar and Ramirez Sebastian, Jose Manuel and Pinazo Durán, Mª Dolores and Salazar Corral, Juan José and Ramírez Sebastián, Ana Isabel (2021) The Role of Autophagy in Eye Diseases. Life, 11 (3). ISSN 2075-1729

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Official URL: https://doi.org/10.3390/life11030189




Abstract

Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.


Item Type:Article
Additional Information:

Received: 6 February 2021 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 27 February 2021

Uncontrolled Keywords:Autophagy; Ocular pathology; Glaucoma; Cataract; Diabetic retinopathy; AMD
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Biology > Cytology
ID Code:64228
Deposited On:03 Mar 2021 11:00
Last Modified:04 Mar 2021 08:46

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