The supplementations with 2-hydroxyoleic acid and n-3 polyunsaturated fatty acids revert oxidative stress in various organs of diet-induced obese mice

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Hunsche, Caroline and Martínez de Toda Cabeza, Irene and Hernández, Oskarina and Jiménez, Beatriz and Díaz, Ligia Esperanza and Marcos, Ascensión and Fuente del Rey, Mónica de la (2020) The supplementations with 2-hydroxyoleic acid and n-3 polyunsaturated fatty acids revert oxidative stress in various organs of diet-induced obese mice. Free Radical Research, 54 (6). pp. 1-12. ISSN 1071-5762; Electronic: 1029-2470

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Official URL: https://doi.org/10.1080/10715762.2020.1800004




Abstract

Obesity and its related diseases have been associated with oxidative stress. Thus, the search for nutritional strategies to ameliorate oxidative stress in obese individuals seems important. We hypothesized that the supplementation with monounsaturated (2-hydroxyoleic acid (2-OHOA)) and with combined n-3 polyunsaturated (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) fatty acids would ameliorate oxidative stress in different organs, including brain, liver, lungs, and kidneys of adult diet-induced obese (DIO) mice. Adult female ICR-CD1 mice were fed a high-fat diet (HFD) for 14 weeks. During the last 6 weeks of HFD feeding, one group of DIO mice received the same HFD, supplemented with 1500 mg of 2-OHOA per kg of HFD and another group with 1500 mg of EPA and 1500 mg of DHA per kg of HFD. At the end of the experiment, several parameters of oxidative stress were assessed. The supplementation with 2- OHOA or with EPA and DHA in DIO mice was able to revert oxidative stress, enhancing the activities of catalase and glutathione reductase, as well as diminishing the activity of xanthine oxidase, the concentration of thiobarbituric acid reactive substances (TBARS) and the ratio between oxidized glutathione and reduced glutathione in several organs. These reached similar values to those of control mice, which were fed a standard diet. These data suggest that supplementation with 2-OHOA and with EPA and DHA could be an effective nutritional intervention to restore an appropriate redox state in DIO mice.


Item Type:Article
Uncontrolled Keywords:Diet-induced obese mice; 2-OHOA; EPA and DHA; Oxidative stress; Organs
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Endocrinology
Medical sciences > Biology > Animal physiology
ID Code:64312
Deposited On:08 Mar 2021 16:49
Last Modified:09 Mar 2021 08:23

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