c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

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Zheng, Kang and Cubero Palero, Francisco Javier and Nevzorova, Yulia Alexandrowna (2017) c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease. Genes, 8 (4). p. 123. ISSN 2073-4425

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Official URL: https://doi.org/10.3390/genes8040123




Abstract

Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.


Item Type:Article
Uncontrolled Keywords:c-Myc Avian Myelocytomatosis Viral Oncogene Homolog; hepatocellular carcinoma; alcoholic liver disease; hepatoblastoma; hepatitis B virus; hepatitis C virus; Liver
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Oncology
Medical sciences > Biology > Cytology
ID Code:64389
Deposited On:18 Mar 2021 17:15
Last Modified:22 Mar 2021 08:16

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