Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis

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Lan-Chow-Wing, Olivier and Confente, Francesca and Herrera-Pérez, Patricia and Isorna Alonso, Esther and Chereguini, Olvido and Rendón, Maria and Falcón, Jack and Muñoz-Cueto, José (2014) Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis. International Journal of Molecular Sciences, 15 (11). pp. 20789-20799. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms151120789




Abstract

Melatonin actions are mediated through G protein-coupled transmembrane receptors. Recently, mt1, mt2, and mel1c melatonin receptors were cloned in the Senegalese sole. Here, their day-night and developmental expressions were analyzed by quantitative PCR. These results revealed distinct expression patterns of each receptor through development. mel1c transcripts were more abundant in unfertilized ovulated oocytes and declined during embryonic development. mt1 and mt2 expression was higher at the earliest stages (2–6 days post-fertilization), decreasing before (mt2) or during (mt1) metamorphosis. Only mt1 and mel1c expression exhibited day-night variations, with higher nocturnal mRNA levels. These results suggest different roles and transcriptional regulation of these melatonin receptors during flatfish development and metamorphosis.


Item Type:Article
Uncontrolled Keywords:melatonin receptors; development; metamorphosis; flatfish
Subjects:Medical sciences > Biology > Fishes
ID Code:64391
Deposited On:18 Mar 2021 17:06
Last Modified:22 Mar 2021 08:17

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