An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity

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Martínez de Toda, Irene and Vida, Carmen and Fuente del Rey, Mónica de la (2017) An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity. International Journal of Molecular Sciences, 18 (7). p. 1598. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms18071598




Abstract

The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity.


Item Type:Article
Uncontrolled Keywords:proliferation; cytokine; aging; longevity; leukocytes
Subjects:Medical sciences > Biology > Cytology
ID Code:64392
Deposited On:16 Mar 2021 18:02
Last Modified:17 Mar 2021 08:34

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