Use of Propylene-Glycol as a Cosolvent for GnRH in Synchronization of Estrus and Ovulation in Sheep



Downloads per month over past year

Santos Jimenez, Zurisaday and Guillen-Gargallo, Sara and Encinas Cerezo, Teresa and Berlinguer, Fiammetta and Veliz-Deras, Francisco G. and Martinez-Ros, Paula and González Bulnes, Antonio (2020) Use of Propylene-Glycol as a Cosolvent for GnRH in Synchronization of Estrus and Ovulation in Sheep. Animals, 10 (5). p. 897. ISSN 2076-2615

[thumbnail of animals-10-00897-v2.pdf] PDF
Creative Commons Attribution.


Official URL:


The foreseen shortage of eCG for estrus synchronization in sheep makes necessary the development of alternative protocols. The aim of the present work was to evaluate the reproductive response of sheep in breeding season to the administration of GnRH using propylene-glycol as a cosolvent and the subcutaneous route for slowing and extending the release of GnRH, as well as the most adequate timing for such administration. In the present study, protocols based on a short-term CIDR treatment and a single subcutaneous dose of GnRH in propylene-glycol at 36 h after CIDR removal induced a similar ovarian response to protocols based on administration of eCG at CIDR removal or intramuscular GnRH in distilled water at 56 h after. In such protocol, 80% of the animals developed estrus in a narrow timing (75% between 36 and 48 h after CIDR removal), and all of them also ovulated in a narrow window (87.5% between 72 and 76 h after CIDR removal, with 62.5% between 72 and 76 h) and showed a similar ovulation rate and plasma progesterone concentrations at the induced estrous cycle. Hence, administration of GnRH in propylene-glycol may constitute an alternative to traditional protocols based on the administration of eCG.

Item Type:Article
Uncontrolled Keywords:eCG; estrus synchronization; GnRH; propylene-glycol; sheep
Subjects:Medical sciences > Veterinary > Sheep
Medical sciences > Veterinary > Veterinary obstetrics
ID Code:64467
Deposited On:13 Apr 2021 17:35
Last Modified:14 Apr 2021 07:39

Origin of downloads

Repository Staff Only: item control page