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Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain

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Miguela Villoldo, Pedro and Hernández, Marta and Moreno Romo, Miguel Ángel and Rodríguez-Lázaro, David and Quesada, Alberto and Domínguez Rodríguez, Lucas and Ugarte Ruiz, María (2019) Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain. Antibiotics, 8 (3). p. 146. ISSN 2079-6382

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Official URL: https://doi.org/10.3390/antibiotics8030146




Abstract

Carbapenems are considered last-resort antimicrobials, especially for treating infections involving multidrug-resistant Gram-negative bacteria. In recent years, extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Gram-negative bacteria have become widespread in hospitals, community settings, and the environment, reducing the range of effective therapeutic alternatives. The use of colistin to treat infection caused by these multi-drug bacteria may favour the selection and persistence of carbapenem-resistant bacteria. In this study, it is described, for the first time to our knowledge, a carbapenemase-producing isolate of Elizabethkingia meningoseptica from healthy pigs in Spain. The isolate we report was recovered during a study to detect colistin-resistant bacteria from faecal samples of healthy food-production animals using a chromogenic selective medium. Unexpectedly, we found an isolate of Elizabethkingia meningoseptica with high Minimum Inhibitory Concentration (MIC) values for several antibiotics tested. Molecular analysis did not show any mcr family genes related with colistin resistance, but two carbapenemase genes, blaB-12_1 and blaGOB-17_1, were detected. This finding in healthy animals could suggest that colistin may favour the selection and persistence of carbapenem-resistant bacteria.


Item Type:Article
Uncontrolled Keywords:carbapenemase; colistin; Elizabethkingia meningoseptica; Antimicrobial resistance
Subjects:Medical sciences > Veterinary > Microbiology
Medical sciences > Veterinary > Veterinary pharmacology
ID Code:64478
Deposited On:23 Mar 2021 16:16
Last Modified:25 Mar 2021 07:40

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