Intrathymic selection and defects in the thymic epithelial cell development

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Garcia-Ceca Hernández, Javier and Montero Herradón, Sara and Zapata González, Agustín (2020) Intrathymic selection and defects in the thymic epithelial cell development. Cells, 9 (10). pp. 1-19. ISSN 2073-4409

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Official URL: https://doi.org/10.3390/cells9102226




Abstract

Intimate interactions between thymic epithelial cells (TECs) and thymocytes (T) have been repeatedly reported as essential for performing intrathymic T-cell education. Nevertheless, it has been described that animals exhibiting defects in these interactions were capable of a proper positive and negative T-cell selection. In the current review, we first examined distinct types of TECs and their possible role in the immune surveillance. However, EphB-deficient thymi that exhibit profound thymic epithelial (TE) alterations do not exhibit important immunological defects. Eph and their ligands, the ephrins, are implicated in cell attachment/detachment and govern, therefore, TEC–T interactions. On this basis, we hypothesized that a few normal TE areas could be enough for a proper phenotypical and functional maturation of T lymphocytes. Then, we evaluated in vivo how many TECs would be necessary for supporting a normal T-cell differentiation, concluding that a significantly low number of TEC are still capable of supporting normal T lymphocyte maturation, whereas with fewer numbers, T-cell maturation is not possible.


Item Type:Article
Uncontrolled Keywords:Thymic epithelial cells; Thymocyte education; Regulatory T-cells; Eph/ephrins
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Cytology
ID Code:64607
Deposited On:24 Mar 2021 13:16
Last Modified:25 Mar 2021 07:28

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