UVA-degradable Collagenase Nanocapsules as a potential treatment for fibrotic disease.

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Moreno Zafra, Víctor Manuel and Meroño, Carolina and Baeza, Alejandro and Usategui Corral, Alicia and Ortiz-Romero, Pablo L. and Pablos, José L. and Vallet Regí, María (2021) UVA-degradable Collagenase Nanocapsules as a potential treatment for fibrotic disease. Pharmaceutics, 13 (4). p. 499. ISSN 1999-4923

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Official URL: https://doi.org/10.3390/pharmaceutics13040499




Abstract

Peyronie and Dupuytren are pathologies characterized by the appearance of localized fibrotic lesions in an organ. These disorders originate from an excessive production of collagen in the tissue provoking dysfunction and functional limitations to the patients. Local administration of collagenase is the most used treatment for these fibrotic-type diseases, but a high lability of the enzyme limits its therapeutic efficacy. Herein, we present a novel methodology for the preparation of collagenase nanocapsules without affecting its enzymatic activity and capable of releasing the enzyme in response to an ultraviolet A (UVA) light stimulus. Polymeric coating around collagenase was formed by free-radical polymerization of acrylamide-type monomers. Their degradation capacity under UVA irradiation was provided by incorporating a novel photocleavable acrylamide-type crosslinker within the polymeric framework. This property allowed collagenase release to be triggered in a controlled manner by employing an easily focused stimulus. Additionally, UVA irradiation presents considerable benefits by itself due to its capacity to induce collagenase production in situ. An expected synergistic effect of collagenase nanocapsules in conjunction with UVA effect may present a promising treatment for these fibrotic diseases.


Item Type:Article
Additional Information:

RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:photolinker; collagenase nanocapsules; fibrotic diseases; collagen; UVA
Subjects:Sciences > Chemistry > Materials
ID Code:64694
Deposited On:12 Apr 2021 15:03
Last Modified:12 Apr 2021 15:03

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