Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype

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Garcia-Contreras, Consolación and Vázquez Gómez, Marta and Barbero, Alicia and Pesantez, José and Zinellu, Angelo and Berlinguer, Fiammetta and González Añover, Pedro and Gonzalez, Jorge and Encinas Cerezo, Teresa and Torres-Rovira, Laura and Nuñez, Yolanda and Ballesteros, Jaime and Ayuso, Miriam and Astiz, Susana and Isabel Redondo, Beatriz and Ovilo, Cristina and González Bulnes, Antonio (2019) Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype. International Journal of Molecular Sciences, 20 (5). p. 1187. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20051187




Abstract

The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found.


Item Type:Article
Uncontrolled Keywords:antioxidants; intrauterine-growth-restriction; pregnancy; swine-model
Subjects:Medical sciences > Veterinary > Veterinary obstetrics
Medical sciences > Veterinary > Animal culture
ID Code:64703
Deposited On:19 Apr 2021 15:19
Last Modified:20 Apr 2021 08:26

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