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The Neurotoxic Role of Extracellular Tau Protein



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Sebastián Serrano, Álvaro and Diego García, Laura de and Díaz Hernández, Miguel (2018) The Neurotoxic Role of Extracellular Tau Protein. International Journal of Molecular Sciences, 19 (4). p. 998. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms19040998


Tauopathies are a class of neurodegenerative diseases associated with the microtubuleassociated protein tau, with Alzheimer’s disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially proposed that phosphorylated and/or aggregated intracellular tau protein was causative of neuronal death. However, recent studies suggest a toxic role for non-phosphorylated and non-aggregated tau when it is located in the brain extracellular space. In this work, we will discuss the neurotoxic role of extracellular tau as well its involvement in the spreading of tau pathologies.

Item Type:Article
Uncontrolled Keywords:tau; TNAP; muscarinic receptors; synaptopathy; Alzheimer’s disease
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Veterinary > Microbiology
ID Code:64706
Deposited On:19 Apr 2021 14:43
Last Modified:14 Jan 2022 12:26

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