Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity

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Garcia-Contreras, Consolacion and Vázquez Gómez, Marta and Torres-Rovira, Laura and Gonzalez, Jorge and Porrini, Esteban and Gonzalez-Colaço, Magali and Isabel Redondo, Beatriz and Astiz, Susana and González Bulnes, Antonio (2018) Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity. International Journal of Molecular Sciences, 19 (3). p. 823. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms19030823




Abstract

Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days. Aging and sarcopenia were related to increased lipid accumulation and cellular dysfunction at both adipose tissue and non-adipose ectopic tissues (liver and pancreas). Obesity concomitant to sarcopenia aggravates the condition by increasing visceral adiposity and causing dyslipidemia, insulin resistance and lipotoxicity in non-adipose tissues. These results support that the Iberian swine model represents certain features of sarcopenia and sarcopenic obesity in humans, paving the way for future research on physiopathology of these conditions and possible therapeutic targets.


Item Type:Article
Uncontrolled Keywords:animal-model; insulin-resistance; lipotoxicity; obesity; sarcopenia; swine
Subjects:Medical sciences > Veterinary > Sheep
Medical sciences > Veterinary > Nutrition and care of the animals
ID Code:64707
Deposited On:19 Apr 2021 14:34
Last Modified:20 Apr 2021 08:12

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