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Sex-related differences in behavioural markers in adult mice for the prediction of lifespan

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Kobayashi, Hikaru and Martínez de Toda Cabeza, Irene and Sanz San Miguel, Luis and Fuente del Rey, Mónica de la (2020) Sex-related differences in behavioural markers in adult mice for the prediction of lifespan. Biogerontology, 22 . pp. 49-62. ISSN 1389-5729, Electronic: 1573-6768

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Official URL: https://doi.org/10.1007/s10522-020-09902-x



Abstract

Finding biomarkers to assess the rate of ageing and consequently, to forecast individual lifespan is a challenge in ageing research. We recently published a mathematical model for lifespan prediction in adult female mice using behavioural parameters such as internal locomotion and time spent in open arms in the hole board (HB) and elevated plus maze (EPM) tests, respectively. Nevertheless, it is still not known if these behavioural variables could be useful in forecasting lifespan in male mice. Therefore, two groups of ICR-CD1 mice, male and female were subjected to the EPM, HB and T-maze tests at the adult age. Mice were monitored until they died and individual lifespans were registered. In general, adult male mice showed more anxiety-like behaviours than females. The mathematical model previously developed in females was validated with the female cohort, but found to be suboptimal for lifespan prediction in males. Thus, a new model for male lifespan prediction was constructed including the behavioural variables that were predictive of lifespan in males: time in the central platform of the EPM, inner locomotion, number of groomings and number and duration of head-dippings in the HB. These results confirm that the higher the anxiety-like behaviour at the adult age, the shorter the lifespan.


Item Type:Article
Uncontrolled Keywords:Male and female mice behaviour; Lifespan prediction; Anxiety and exploratory; Behaviour; Multiple lineal regression
Subjects:Medical sciences > Medicine > Geriatrics
Medical sciences > Biology > Animal physiology
ID Code:64709
Deposited On:07 Apr 2021 11:51
Last Modified:08 Apr 2021 07:59

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