Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma



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Morales Fernández, Laura and Benito Pascual, Blanca and Pérez García, Pilar and Perucho González, Lucía and Sáenz Francés, Federico and Santos Bueso, Enrique and García Bella, Javier and Sánchez Jean, Rubén and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2021) Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma. Canadian Journal of Ophthalmology . 7 p.. ISSN 1715-3360 ; E-ISSN: 0008-4182 (In Press)

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Objective: To describe corneal densitometry, topographic measurements, and biomechanical properties in patients with primary congenital glaucoma (PCG) and healthy patients. To examine correlations between variables and determine their glaucoma diagnostic capacity.
Methods: This was a cross-sectional, case-control study conducted in 50 eyes of 50 patients with PCG (G1) and 40 eyes of 40 healthy patients (G2). The variables determined in each participant were: intraocular pressure, best corrected visual acuity (BCVA), corneal densitometry, topographic data using the Pentacam HR-Scheimpflug imaging system (Oculus Optikgerate GmbH, Wetzlar, Germany), and corneal hysteresis (CH) and corneal resistance factor (CRF) using the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Depew, NY).
Results: Overall densitometry was significatively higher in the PCG group (G1: 17.94 ± 4.99 vs G2: 13.25 ± 1.96, p < 0.001). CH (G1: 8.02 ± 11.35 vs G2: 11.35 ± 1.42, p < 0.001) and CRF (G1: 9.48 ± 2.83 vs G2: 10.77 ± 1.34, p < 0.001) were lower in the glaucoma group. Mean posterior, central, and anterior elevation and mean keratometry were higher in G1 (p < 0.05). In the PCG group, overall densitometry showed significant correlation with CH (r = –0.321, p = 0.028) and with BCVA (r = −0.498, p = 0.002). AUCs (areas under the curve) for CH and overall densitometry were high (0.839 and 0.899 respectively) and the best overall densitometry; CH and CRF cutoffs were 14.0, 9.3 and 9.2 respectively.
Conclusion: Densitometry is increased, and biomechanical corneal properties are decreased in patients with PCG. Densitometry and visual acuity showed a negative and significant correlation, so this measurement could be used as an indirect parameter of BCVA in the clinical practice.

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Available online 10 February 2021.

Uncontrolled Keywords:Corneal densitometry; Corneal biomechanica ; Glaucoma ; Primary congenital glaucoma; topographic measurements ; Cornea
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Optometry
Medical sciences > Optics > Imaging systems
ID Code:64836
Deposited On:14 Apr 2021 15:45
Last Modified:15 Apr 2021 08:03

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