Publication: Eficacia de un nuevo alquilfosfolípido frente a la leishmaniosis canina experimental por Leishmania infantum
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2021
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Universidad Complutense de Madrid
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Abstract
La leishmaniosis es una enfermedad vectorial, ampliamente distribuida, causada por especies del género Leishmania. El curso clínico se relaciona con la especie involucrada y la funcionalidad del sistema inmunológico del hospedador. La leishmaniosis visceral, provocada por L. donovani y L. infantum, es la afección más grave. Los perros pueden ser infectados por varias especies de Leishmania y se consideran el principal reservorio de infecciones humanas por L. infantum (leishmaniosis visceral zoonótica, LVZ). La leishmaniasis canina (LCan) es muy frecuente y constituye una patología veterinaria de primer orden en áreas endémicas. No existe vacuna humana disponible y la inmunoprofilaxis frente a la LCan tiene numerosas limitaciones, el control ambiental es inviable y la eficacia del sacrificio de perros infectados es discutible. Por tanto, el control de la LCan – y la LVZ – reside en el uso de repelentes y, principalmente, en la quimioterapia de los perros infectados. Sin embargo, el arsenal terapéutico incluye los mismos compuestos utilizados para el tratamiento de la leishmaniasis humana y todos ellos presentan importantes inconvenientes en términos de eficacia, toxicidad y/o fenómenos de resistencia...
Leishmaniasis is a widely distributed vectorial disease caused by species of the genus Leishmania. Disease outcome depends on the Leishmania species involved and the functionality of the host’s immune response. Visceral leishmaniasis, produced L. donovani and L. infantum, is the most severe condition. Dogs can be infected by a variety of Leishmania species and they are considered the main reservoir for human infections by L.infantum (zoonotic visceral leishmaniasis, ZVL). Canine leishmaniasis (CanL) is prevalent and a first order veterinary pathology in endemic areas. No human vaccine is available and the currently marketed veterinary vaccines have limitations, environmental control is unfeasible and efficacy of dog culling has been challenged. Therefore, the control of CanL – and ZVL – relies on the use of repellents and, mainly, the treatment of infected dogs. However, the available therapeutic arsenal includes the same compounds used against human leishmaniasis and all of them have serious drawbacks considering efficacy, toxicity and resistance phenomena...
Leishmaniasis is a widely distributed vectorial disease caused by species of the genus Leishmania. Disease outcome depends on the Leishmania species involved and the functionality of the host’s immune response. Visceral leishmaniasis, produced L. donovani and L. infantum, is the most severe condition. Dogs can be infected by a variety of Leishmania species and they are considered the main reservoir for human infections by L.infantum (zoonotic visceral leishmaniasis, ZVL). Canine leishmaniasis (CanL) is prevalent and a first order veterinary pathology in endemic areas. No human vaccine is available and the currently marketed veterinary vaccines have limitations, environmental control is unfeasible and efficacy of dog culling has been challenged. Therefore, the control of CanL – and ZVL – relies on the use of repellents and, mainly, the treatment of infected dogs. However, the available therapeutic arsenal includes the same compounds used against human leishmaniasis and all of them have serious drawbacks considering efficacy, toxicity and resistance phenomena...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Sanidad Animal, leída el 27-01-2021