Publication: Daño tisular, respuesta inmune y tolerancia infecciones en patologías asociadas a la sobrecarga de hierro
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2021-04-14
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Universidad Complutense de Madrid
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Abstract
La sobrecarga del hierro engloba una serie de patologías que pueden tener un origen primario, principalmente genético; o secundario. En ellas, el metabolismo y la homeostasis del hierro se ven alterados favoreciendo la deposición del metal, que puede tener efectos nocivos en los órganos donde se deposita, siendo los más comunes el hígado, el corazón y las glándulas endocrinas. La hemocromatosis hereditaria (HH) de tipo 1 es la más común de las sobrecargas de hierro primarias. Este trastorno se produce por mutaciones en el gen HFE, y se caracteriza por una alta concentración de hierro sérico y un déficit en los niveles de hepcidina, el principal regulador del metabolismo del hierro. Existen otros tipos de HH con una frecuencia tan baja que se consideran enfermedades raras: HH de tipo 2, tipo 3, tipo 4 y tipo 5. Por otro lado, la sobrecarga de hierro secundaria es habitualmente consecuencia de repetidas transfusiones terapéuticas de sangre en anemias de diferente índole, y también por una ingesta excesiva de hierro en la dieta o consumo de alcohol...
Iron overload involves a variety of pathologies that could have a primary origin, mainly genetical; or secondary. In these, iron metabolism and homeostasis are altered, causing metal accumulation, a process which can have harmful effects on organs where it is deposited, most commonly liver, heart and endocrine glands. Hereditary hemochromatosis (HH) type 1 is the most prevalent of the primary iron overloads. This disorder is caused by mutations in HFE gene and is characterized by a high concentration of serum iron and a deficit in the levels of hepcidin, the main regulator of iron metabolism. There are other types of HH with such a low frequency that they are considered rare diseases: HH type 2, type 3, type 4 and type 5. On the other hand, secondary iron overload is usually a consequence of reiterative therapeutic blood transfusions in different types of anaemia, and due to an excess of dietary iron intake or alcohol consumption...
Iron overload involves a variety of pathologies that could have a primary origin, mainly genetical; or secondary. In these, iron metabolism and homeostasis are altered, causing metal accumulation, a process which can have harmful effects on organs where it is deposited, most commonly liver, heart and endocrine glands. Hereditary hemochromatosis (HH) type 1 is the most prevalent of the primary iron overloads. This disorder is caused by mutations in HFE gene and is characterized by a high concentration of serum iron and a deficit in the levels of hepcidin, the main regulator of iron metabolism. There are other types of HH with such a low frequency that they are considered rare diseases: HH type 2, type 3, type 4 and type 5. On the other hand, secondary iron overload is usually a consequence of reiterative therapeutic blood transfusions in different types of anaemia, and due to an excess of dietary iron intake or alcohol consumption...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, leída el 02-02-2021