Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan‐Stabilized Selenium Nanoparticles.

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Estévez Sánchez, Héctor and García Calvo, Estefanía and Rivera-Torres, José and Vallet Regí, María and González Ortiz, Blanca and Luque García, José Luis (2021) Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan‐Stabilized Selenium Nanoparticles. Pharmaceutics, 13 . p. 356. ISSN 1999-4923

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Official URL: https://doi.org/10.3390/pharmaceutics13030356




Abstract

Selenium nanoparticles (SeNPs) have been receiving special attention in recent years due to their antioxidant capacity and antitumor properties. However, the mechanisms associated with these properties remain to be elucidated. For this reason, a global transcriptome analysis has been designed in this work and it was carried out using human hepatocarcinoma cells and chitosan‐ stabilized SeNPs (Ch‐SeNPs) to identify new targets and pathways related to the antitumor mechanisms associated with Ch‐SeNPs. The results obtained confirm the alteration of the cell cycle and the effect of Ch‐SeNPs on different tumor suppressors and other molecules involved in key mechanisms related to cancer progression. Furthermore, we demonstrated the antioxidant properties of these nanoparticles and their capacity to induce senescence, which was further confirmed through the measurement of β‐galactosidase activity.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID K-4773-2015 (Blanca González Ortiz)
ORCID 0000-0002-0493-6071 (Blanca González Ortiz)

Uncontrolled Keywords:selenium nanoparticles; transcriptome analysis; senescence; antioxidant capacity; tumor suppressors; antitumor agent
Subjects:Sciences > Chemistry > Materials
ID Code:64924
Deposited On:21 Apr 2021 14:00
Last Modified:21 Apr 2021 14:00

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