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Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations

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Martínez, Paula J. and Agudiez, Marta and Molero, Dolores and Martín Lorenzo, Marta and Baldán Martín, Montserrat and Santiago Hernández, Aránzazu and García Segura, Juan Manuel and Madruga, Felipe and Cabrera Sierra, Martha and Calvo, Eva and Ruiz Hurtado, Gema and Barderas, María G. and Vivanco, Fernando and Ruilope, Luis M. and Alvarez-Llamas, Gloria (2020) Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations. Journal of Molecular Medicine, 98 . pp. 1603-1613. ISSN 1432-1440

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Official URL: https://doi.org/10.1007/s00109-020-01976-x



Abstract

The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention.


Item Type:Article
Uncontrolled Keywords:biomarkers; cardiovascular risk; elderly; early prevention; lifetime risk; metabolomics
Subjects:Medical sciences > Medicine > Nephrology and Urology
ID Code:64935
Deposited On:16 Apr 2021 12:31
Last Modified:20 Apr 2021 11:49

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