Repeatability of macular and optic nerve head measurements by optical coherence tomography angiography in healthy children



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Pérez García, Pilar and Morales Fernández, Laura and Fernández Vigo, José Ignacio and Sáenz Francés, Federico and Burgos Blasco, Bárbara and Güemes Villahoz, Noemi and Oribio Quinto, Carlos and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2021) Repeatability of macular and optic nerve head measurements by optical coherence tomography angiography in healthy children. Current Eye Research . ISSN 0271-3683; 1460-2202 (e) (In Press)

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Aims: To evaluate the repeatability of the peripapillary and macular vascular parameters using optical coherence tomography angiography (OCT-A) in healthy children.
Materials and methods: Cross-sectional study including 34 eyes of 34 healthy children. After a complete medical examination, two consecutive OCT-A exams were done using AngioPlex Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA, USA) in the same session. The scan area used was 6 × 6 mm for the analysis of the superficial vascular plexus (SVP) in the macula, and 4.5 × 4.5 mm for the peripapillary plexus. To study the repeatability of the measurements, the intraclass correlation coefficient (ICC) and the coefficient of variation (CV) of each pair of exams were calculated.
Results: The mean age of the children included was 10.77 ± 2.49 years (range 6 to 15 years). Good and excellent ICCs were obtained for all the parameters considered. Peripapillary vascular parameters showed greater reproducibility than macular ones (global peripapillary perfusion density (pPD): ICC = 0.834 CV = 0.89% vs. whole macular area PD (w-mPD): ICC = 0.697 CV = 3.49%; global peripapillary flux index (FI): ICC = 0.858 CV = 1.28%; whole macular area vascular density (VD): ICC = 0.699 CV = 3.30%). Amongst the macular parameters, the characteristics of the foveal avascular zone (FAZ) were the ones showing higher rates of repeatability (FAZ circularity: ICC = 0.858 CV = 8.83%).
Conclusion: OCT-A is a non-invasive, time-efficient technology that may be useful in the evaluation of the retinal and peripapillary vascular network in healthy children. The repeatability of the measures will allow the follow-up and evaluation of any change occurring in the macular or optic nerve perfusion.

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Received 25 November 2020; Revised 14 March 2021; Accepted 18 March 2021; Published online: 13 Apr 2021.

Uncontrolled Keywords:Optical coherence; Tomography angiography; Vessel density; Macula; Optic nerve head; Repeatability
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:65009
Deposited On:22 Apr 2021 12:46
Last Modified:26 Apr 2021 19:40

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