Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition



Downloads per month over past year

Garcia-Contreras, Consolacion and Vázquez Gómez, Marta and Astiz, Susana and Torres-Rovira, Laura and Sanchez-Sanchez, Raul and Gomez-Fidalgo, Ernesto and Gonzalez, Jorge and Isabel Redondo, Beatriz and Rey Muñoz, Ana Isabel and Ovilo, Cristina and González Bulnes, Antonio (2017) Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition. International Journal of Molecular Sciences, 18 (6). p. 1171. ISSN 1422-0067

[thumbnail of ijms-18-01171-v2.pdf] PDF
Creative Commons Attribution.


Official URL: https://doi.org/10.3390/ijms18061171


Sex-related differences in lipid availability and fatty acid composition during swine foetal development were investigated. Plasma cholesterol and triglyceride concentrations in the mother were strongly related to the adequacy or inadequacy of foetal development and concomitant activation of protective growth in some organs (brain, heart, liver and spleen). Cholesterol and triglyceride availability was similar in male and female offspring, but female foetuses showed evidence of higher placental transfer of essential fatty acids and synthesis of non-essential fatty acids in muscle and liver. These sex-related differences affected primarily the neutral lipid fraction (triglycerides), which may lead to sex-related postnatal differences in energy partitioning. These results illustrate the strong influence of the maternal lipid profile on foetal development and homeorhesis, and they confirm and extend previous reports that female offspring show better adaptive responses to maternal malnutrition than male offspring. These findings may help guide dietary interventions to ensure adequate fatty acid availability for postnatal development.

Item Type:Article
Uncontrolled Keywords:fatty-acids; foetus; lipids; metabolism; nutrition; sex
Subjects:Medical sciences > Veterinary > Veterinary obstetrics
ID Code:65037
Deposited On:21 Apr 2021 16:49
Last Modified:28 Apr 2021 07:53

Origin of downloads

Repository Staff Only: item control page