Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet



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Díaz, María and Guadamuro, Lucía and Espinosa Martos, Irene and Mancabelli, Leonardo and Jiménez, Santiago and Molinos-Norniella, Cristina and Pérez-Solis, David and Milani, Christian and Rodríguez Gómez, Juan Miguel and Ventura, Marco and Bousoño, Carlos and Gueimonde, Miguel and Margolles, Abelardo and Díaz, Juan and Delgado, Susana (2018) Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet. Nutrients, 10 (10). p. 1481. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu10101481


Cow’s milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates. After this period, stool samples were obtained and tolerance development was evaluated by oral challenges. A control group of 10 age-matched healthy infants on an unrestricted diet were included in the study. Microbiota composition, short-chain fatty acids, calprotectin, and transforming growth factor (TGF)-β1 levels were determined in fecal samples from both groups. Infants with NIM-CMPA that consumed vegetable protein-based formulas presented microbiota colonization patterns different from those fed with an extensively hydrolyzed formula. Differences in microbiota composition and fecal parameters between NIM-CMPA and healthy infants were observed. Non-allergic infants showed a significantly higher proportion of Bacteroides compared to infants with NIM-CMPA. The type of protein hydrolysate was found to determine gut microbiota colonization and influence food allergy resolution in NIM-CMPA cases.

Item Type:Article
Uncontrolled Keywords:fecal microbiota; protein hydrolyzed formulas; cow’s milk protein; tolerance acquisition; non-IgE mediated allergy
Subjects:Medical sciences > Medicine > Allergy
Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Gynecology and Obstetrics
ID Code:65107
Deposited On:27 Apr 2021 15:06
Last Modified:28 Apr 2021 08:01

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