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Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity?



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Pamplona, Reinald and Jové, Mariona and Mota-Martorell, Natalia and Barja de Quiroga, Gustavo (2021) Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity? FEBS Journal . pp. 1-22. ISSN 1742-464X; Electronic: 1742-4658

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Official URL: https://doi.org/10.1111/febs.15714


Complex I, a component of the electron transport chain, plays a central functional role in cell bioenergetics and the biology of free radicals. The structural and functional N module of complex I is one of the main sites of the generation of free radicals. The NDUFV2 subunit/N1a cluster is a component of this module. Furthermore, the rate of free radical production is linked to animal longevity. In this review, we explore the hypothesis that NDUFV2 is the only conserved core subunit designed with a regulatory function to ensure correct electron transfer and free radical production, that low gene expression and protein abundance of the NDUFV2 subunit is an evolutionary adaptation needed to achieve a longevity phenotype, and that these features are determinants of the lower free radical generation at the mitochondrial level and a slower rate of aging of long-lived animals.

Item Type:Article
Uncontrolled Keywords:Animal longevity; Complex I; Mitochondria; N1a cluster; NDUFV2 subunit; Reactive oxygen species; Superoxide radical
Subjects:Medical sciences > Biology > Biochemistry
Medical sciences > Biology > Animal physiology
Medical sciences > Biology > Mammals
ID Code:65179
Deposited On:29 Apr 2021 09:25
Last Modified:30 Apr 2021 07:39

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