Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression

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Jiménez Santos, María A. and Sáenz Francés, Federico and Sánchez Jean, Rubén and Martínez de la Casa, Jose Maria and García Feijoo, Julián and Jañez Escalada, Luis (2021) Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression. Graefe's Archive for Clinical and Experimental Ophthalmology . ISSN 0721-832X; 1435-702X (e) (In Press)

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Official URL: https://dx.doi.org/10.1007/s00417-021-05212-1




Abstract

Purpose: To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG).
Methods: In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Parrish and Anderson classification modified for Octopus perimetry and followed up until glaucomatous progression development; otherwise, observations were censored in October 2018. Cox regression was used to obtain hazard ratios (HR) to evaluate baseline variables (CH, central corneal thickness, gender, age IOP and glaucoma family history) as risk factors for perimetric glaucoma progression. A likelihood ratio test for interaction was performed in order to assess the effect of the combination of CH and CCT on the risk of progression.
Results: Of the cohort of 1573 patients, 11.38% developed early-stage POAG progression during the follow-up. The mean follow-up time was 3.28 ± 1.92 years. Patients without progression had a higher CH (11.35 ± 1.43 vs 9.07 ± 1.69 mmHg; p < 0.001) and CCT (570.75 ± 17.71 vs 554.51 ± 23.20; p < 0.001). In the multivariate analysis, each 1 mmHg of lower CH was associated with an increase of 2.13 times in the HR of progression (95% CI: 1.92–2.32; p < 0.001). CH hazard ratio was modified by CCT, with higher values of CCT and CH resulting in a higher HR of early glaucoma progression (p < 0.001).
Conclusions: CH can be considered as a risk factor of progression in early-stage POAG. The risk associated with CH changed depending on CCT values, acting synergistically slowing the risk of glaucoma progression with higher values.


Item Type:Article
Additional Information:

Received: 2 September 2020. Revised: 9 March 2021. Accepted: 19 April 2021. Published online: 7 May 2021.

Uncontrolled Keywords:Perimetry; Primary open-angle glaucoma; Progression; Corneal hysteresis; Risk factors
Subjects:Medical sciences > Medicine > Ophtalmology
ID Code:65713
Deposited On:03 Jul 2021 09:48
Last Modified:06 Jul 2021 10:30

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