Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges



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Martínez-González, José and Varona, Saray and Cañes, Laia and Galán, María and Briones, Ana and Cachofeiro Ramos, Victoria and Rodríguez, Cristina (2019) Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges. Biomolecules, 9 (10). p. 610. ISSN 2218-273X

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Official URL: https://doi.org/10.3390/biom9100610


Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, differentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular stiffness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets.

Item Type:Article
Uncontrolled Keywords:lysyl oxidases; cardiovascular diseases; atherosclerosis; aortic aneurysm; vascular calcification; vascular stiffness; myocardial fibrosis
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Physiology
ID Code:65736
Deposited On:31 May 2021 14:34
Last Modified:01 Jun 2021 06:55

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