Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame

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Ramadori, Pierluigi and Cubero Palero, Francisco Javier and Liedtke, Christian and Trautwein, Christian and Nevzorova, Yulia Alexandrowna (2017) Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers, 9 (12). p. 130. ISSN 2072-6694

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Official URL: https://doi.org/10.3390/cancers9100130




Abstract

Primary tumors of the liver represent the fifth most common type of cancer in the world and the third leading cause of cancer-related death. Case-control studies from different countries report that chronic ethanol consumption is associated with an approximately 2-fold increased odds ratio for hepatocellular carcinoma (HCC). Despite the substantial epidemiologic data in humans demonstrating that chronic alcohol consumption is a major risk factor for HCC development, the pathways causing alcohol-induced liver cancer are poorly understood. In this overview, we summarize the epidemiological evidence for the association between alcohol and liver cancer, review the genetic, oncogenic, and epigenetic factors that drive HCC development synergistically with ethanol intake and discuss the essential molecular and metabolic pathways involved in alcohol-induced liver tumorigenesis.


Item Type:Article
Uncontrolled Keywords:alcohol; hepatocellular carcinoma; acetaldehyde; oxidative stress; apoptosis
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Oncology
ID Code:65739
Deposited On:31 May 2021 14:24
Last Modified:01 Jun 2021 06:58

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