Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4

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Valencia Mahón, Jaris and Martínez Fernández de Sevilla, Lidia and Fraile Ramos, Alberto and Sacedón Ayuso, Rosa and Jiménez, Eva and Vicente López, Ángeles and Varas Fajardo, Alberto (2019) Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4. Cells, 8 (7). p. 722. ISSN 2073-4409

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Official URL: https://doi.org/10.3390/cells8070722




Abstract

Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew M1-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells.


Item Type:Article
Uncontrolled Keywords:acute lymphoblastic leukaemia; BMP4; dendritic cells; macrophages; tumour immune microenvironment
Subjects:Medical sciences > Medicine > Medical microbiology
Medical sciences > Medicine > Oncology
ID Code:65743
Deposited On:31 May 2021 14:09
Last Modified:01 Jun 2021 07:01

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