The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension

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Aller Reyero, María de los Ángeles and Blanco-Rivero, Javier and Arias, Natalia and Santamaria, Luis and Arias Pérez, Jaime (2019) The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension. Cells, 8 (7). p. 658. ISSN 2073-4409

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Official URL: https://doi.org/10.3390/cells8070658




Abstract

Portal hypertension is a common complication of liver disease, either acute or chronic. Consequently, in chronic liver disease, such as the hypertensive mesenteric venous pathology, the coexisting inflammatory response is classically characterized by the splanchnic blood circulation. However, a vascular lymphatic pathology is produced simultaneously with the splanchnic arterio-venous impairments. The pathological increase of the mesenteric venous pressure, by mechanotransduction of the venous endothelium hyperpressure, causes an inflammatory response involving the subendothelial mast cells and the lymphatic endothelium of the intestinal villi lacteal. In portal hypertension, the intestinal lymphatic inflammatory response through the development of mesenteric-systemic lymphatic collateral vessels favors the systemic diffusion of substances with a molecular pattern associated with damage and pathogens of intestinal origin. When the chronic hepatic insufficiency worsens the portal hypertensive inflammatory response, the splanchnic lymphatic system transports the hyperplasied intestinal mast cells to the mesenteric lymphatic complex. Then, an acquired immune response regulating a new hepato-intestinal metabolic scenario is activated. Therefore, reduction of the hepatic metabolism would reduce its key centralized functions, such as the metabolic, detoxifying and antioxidant functions which would try to be substituted by their peroxisome activity, among other functions of the mast cells.


Item Type:Article
Uncontrolled Keywords:lymphatics; mast cells; peroxisomes; portal hypertension
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
ID Code:65744
Deposited On:25 May 2021 15:14
Last Modified:26 May 2021 06:24

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