Publication: Estudio bioinformático de muestras clínicas en la infección de Helicobacter pylori: importancia del microbioma
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2021-05-31
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Universidad Complutense de Madrid
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Abstract
Helicobacter pylori es una bacteria Gram negativa con forma espiral, que lleva colonizando al ser humano desde hace más de 50.000 años, actualmente infecta entre el 25 y 80% de la población mundial. Está asociada a múltiples patologías gástricas, como gastritis, úlcera y cáncer gástrico. Estas patologías no se distribuyen de manera uniforme entre poblaciones con una tasa de infección similar y se ha propuesto, como un factor clave en la evolución de las patologías gástricas, a la microbiota gástrica no-H. pylori. Las nuevas técnicas proteómicas y de secuenciación masiva, junto a nuevos programas bioinformáticos que nos ayudan a procesar la información que este tipo de estudios produce, nos abren un nuevo horizonte de posibilidades. El objetivo principal de este estudio es la utilización de las técnicas proteómicas y de secuenciación masiva, junto a un programa de elaboración propia, en el análisis de la microbiota gástrica para identificar variaciones en pacientes infectados o no por H. pylori en función del estado de infección, patología gástrica asociada y país de residencia...
Helicobacter pylori is a Gram-negative spiral bacterium, which has been colonizing humans for more than 50,000 years, currently infecting between 25 and 80% of the population. It is associated with multiple gastric pathologies, such as gastritis, ulcer and gastric cancer. These pathologies are not evenly distributed among populations with a similar infection rate and the non-H. pylori gastric microbiota has been proposed as a key factor in the evolution of gastric pathologies. New proteomic and mass sequencing techniques, together with new bioinformatics programs, wich help us to process the information of this type of studies, open a new horizon of possibilities for us. The main objective of this study is the use of proteomic techniques and massive sequencing, together with a program of our own elaboration, in the analysis of gastric microbiota in patients infected or not by H. pylori depending on the state of infection, gastric pathology and country of residence...
Helicobacter pylori is a Gram-negative spiral bacterium, which has been colonizing humans for more than 50,000 years, currently infecting between 25 and 80% of the population. It is associated with multiple gastric pathologies, such as gastritis, ulcer and gastric cancer. These pathologies are not evenly distributed among populations with a similar infection rate and the non-H. pylori gastric microbiota has been proposed as a key factor in the evolution of gastric pathologies. New proteomic and mass sequencing techniques, together with new bioinformatics programs, wich help us to process the information of this type of studies, open a new horizon of possibilities for us. The main objective of this study is the use of proteomic techniques and massive sequencing, together with a program of our own elaboration, in the analysis of gastric microbiota in patients infected or not by H. pylori depending on the state of infection, gastric pathology and country of residence...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Microbiología, leída el 19/02/2021