Metallic Nanoparticles—friends or foes in the battle against antibiotic-Resistant Bacteria?

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Amaro Torres, Francisco and Morón García, Álvaro and Díaz del Toro, Silvia and Martín González, Ana María and Gutiérrez Fernández, Juan Carlos (2021) Metallic Nanoparticles—friends or foes in the battle against antibiotic-Resistant Bacteria? Microorganisms, 9 (2). pp. 1-10. ISSN Electronic: 2076-2607

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Official URL: https://www.mdpi.com/2076-2607/9/2/364



Abstract

The rapid spread of antibiotic resistances among bacteria demands novel strategies for infection control, and metallic nanoparticles appear as promising tools because of their unique size and tunable properties that allow their antibacterial effects to be maximized. Furthermore, their diverse mechanisms of action towards multiple cell components have suggested that bacteria could not easily develop resistance against nanoparticles. However, research published over the last decade has proven that bacteria can indeed evolve stable resistance mechanisms upon continuous exposure to metallic nanoparticles. In this review, we summarize the currently known individual and collective strategies employed by bacteria to cope with metallic nanoparticles. Importantly, we also discuss the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination and that might constitute a challenge for the implementation of nanoparticles as antibacterial agents. Overall, studies discussed in this review point out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control.


Item Type:Article
Uncontrolled Keywords:Nanoparticles; Heavy metals; Resistance; Antibiotic resistance; Oxidative stress
Subjects:Medical sciences > Biology > Microbiology
ID Code:65866
Deposited On:01 Jun 2021 13:31
Last Modified:02 Jun 2021 07:23

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