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Influence of Diet, Menstruation and Genetic Factors on Iron Status: A Cross-Sectional Study in Spanish Women of Childbearing Age



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Blanco-Rojo, Ruth and Toxqui, Laura and López Parra, Ana María and Baeza Richer, Carlos Ignacio and Pérez-Granados, Ana and Arroyo Pardo, Eduardo and Vaquero, M. (2014) Influence of Diet, Menstruation and Genetic Factors on Iron Status: A Cross-Sectional Study in Spanish Women of Childbearing Age. International Journal of Molecular Sciences, 15 (3). pp. 4077-4087. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms15034077


The aim of this study was to investigate the combined influence of diet, menstruation and genetic factors on iron status in Spanish menstruating women (n = 142). Dietary intake was assessed by a 72-h detailed dietary report and menstrual blood loss by a questionnaire, to determine a Menstrual Blood Loss Coefficient (MBLC). Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs1375515 (CACNA2D3 gene); and rs1800562 and rs1799945 (HFE gene, mutations C282Y and H63D, respectively). Iron biomarkers were determined and cluster analysis was performed. Differences among clusters in dietary intake, menstrual blood loss parameters and genotype frequencies distribution were studied. A categorical regression was performed to identify factors associated with cluster belonging. Three clusters were identified: women with poor iron status close to developing iron deficiency anemia (Cluster 1, n = 26); women with mild iron deficiency (Cluster 2, n = 59) and women with normal iron status (Cluster 3, n = 57). Three independent factors, red meat consumption, MBLC and mutation C282Y, were included in the model that better explained cluster belonging (R2 = 0.142, p < 0.001). In conclusion, the combination of high red meat consumption, low menstrual blood loss and the HFE C282Y mutation may protect from iron deficiency in women of childbearing age. These findings could be useful to implement adequate strategies to prevent iron deficiency anemia.

Item Type:Article
Uncontrolled Keywords:iron deficiency; red meat consumption; menstrual blood loss; SNP; HFE gene; menstruating women
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Gynecology and Obstetrics
ID Code:65876
Deposited On:07 Jun 2021 17:48
Last Modified:08 Jun 2021 18:29

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