Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer

Impacto

Downloads

Downloads per month over past year

Verde, Zoraida and Santiago, Catalina and Chicharro, Luis Miguel and Reinoso-Barbero, Luis and Tejerina, Alejandro and Bandrés Moya, Fernando and Gómez-Gallego, Félix (2016) Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. International Journal of Molecular Sciences, 17 (10). p. 1726. ISSN 1422-0067

[thumbnail of ijms-17-01726.pdf]
Preview
PDF
Creative Commons Attribution.

243kB

Official URL: https://doi.org/10.3390/ijms17101726




Abstract

Introduction: Tobacco smoke contains many potentially harmful compounds that may act differently and at different stages in breast cancer development. The focus of this work was to assess the possible role of cigarette smoking (status, dose, duration or age at initiation) and polymorphisms in genes coding for enzymes involved in tobacco carcinogen metabolism (CYP1A1, CYP2A6) or in DNA repair (XRCC1, APEX1, XRCC3 and XPD) in breast cancer development.
Methods: We designed a case control study with 297 patients, 217 histologically verified breast cancers (141 smokers and 76 non-smokers) and 80 healthy smokers in a cohort of Spanish women.
Results: We found an association between smoking status and early age at diagnosis of breast cancer. Among smokers, invasive carcinoma subtype incidence increased with intensity and duration of smoking (all Ptrend < 0.05). When smokers were stratified by smoking duration, we only observed differences in long-term smokers, and the CYP1A1 Ile462Ile genotype was associated with increased risk of breast cancer (OR = 7.12 (1.98–25.59)).
Conclusions: Our results support the main effect of CYP1A1 in estrogenic metabolism rather than in tobacco carcinogen activation in breast cancer patients and also confirmed the hypothesis that CYP1A1 Ile462Val, in association with long periods of active smoking, could be a breast cancer risk factor.


Item Type:Article
Uncontrolled Keywords:breast cancer; long-term smoking; CYP1A; DNA repair genes
Subjects:Medical sciences > Medicine > Medical microbiology
Medical sciences > Medicine > Oncology
ID Code:65877
Deposited On:10 Jun 2021 14:50
Last Modified:10 Jun 2021 15:34

Origin of downloads

Repository Staff Only: item control page