Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model

Impacto

Downloads

Downloads per month over past year

Ibarrola, Jaime and Martínez-Martínez, Ernesto and Sádaba, J. and Arrieta, Vanessa and García-Peña, Amaia and Álvarez, Virginia and Fernández-Celis, Amaya and Gainza, Alicia and Rossignol, Patrick and Cachofeiro Ramos, Victoria and López-Andrés, Natalia (2017) Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model. International Journal of Molecular Sciences, 18 (8). p. 1664. ISSN 1422-0067

[thumbnail of ijms-18-01664.pdf] PDF
Creative Commons Attribution.

11MB

Official URL: https://doi.org/10.3390/ijms18081664




Abstract

Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constriction, vascular Gal-3 expression was up-regulated in male Wistar rats. Gal-3 overexpression was accompanied by an increase in the aortic media layer thickness, enhanced total collagen, and augmented expression of fibrotic mediators. Further, vascular inflammatory markers as well as inflammatory cells content were greater in aorta from PO rats. MCP treatment (100 mg/kg/day) prevented the increase in Gal-3, media thickness, fibrosis, and inflammation in the aorta of PO rats. Gal-3 levels were higher in AVs from PO rats. This paralleled enhanced AV fibrosis, inflammation, as well as greater expression of calcification markers. MCP treatment prevented the increase in Gal-3 as well as fibrosis, inflammation, and calcification in AVs. Overall, Gal-3 is overexpressed in aorta and AVs from PO rats. Gal-3 pharmacological inhibition blocks aortic and AV remodeling in experimental PO. Gal-3 could be a new therapeutic approach to delay the progression and the development of aortic remodeling and AV calcification in PO.


Item Type:Article
Uncontrolled Keywords:Galectin-3; pressure overload; aorta; valve
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Physiology
ID Code:65878
Deposited On:08 Jun 2021 16:10
Last Modified:08 Jun 2021 17:57

Origin of downloads

Repository Staff Only: item control page