Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats

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Rancan, Lisa and Paredes Royano, Sergio Damián and García Martín, Cruz and González, Pablo and Rodríguez-Bobada, Cruz and Calvo Soto, Mario and Hyacinthe, Bryan and Vara Ameigeiras, Elena Mª and Fernández-Tresguerres Hernández, Jesús Ángel (2018) Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. International Journal of Molecular Sciences, 19 (7). p. 2097. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms19072097




Abstract

Aging is associated with an increase in stroke risk. Melatonin, a potent free radical scavenger and broad spectrum antioxidant, has been shown to counteract inflammation and apoptosis in brain injury. However, little is known on the possible protective effects of melatonin in aged individuals affected by brain ischemia. Also, using melatonin before or after an ischemic stroke may result in significantly different molecular outcomes. The objective of the present study was to compare the effects of pre-ischemia vs. post-ischemia melatonin administration in an ischemic lesion in the cortex and hippocampus of senescent Wistar rats. An obstruction of the middle cerebral artery (MCA) to 18-month-old animals was performed. In general, animals treated with melatonin from 24 h prior to surgery until 7 days after the surgical procedure (PrevT) experienced a significant decrease in the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), glial fibrillary acidic protein (GFAP), Bcl-2-associated death promoter (BAD), and Bcl-2-associated X protein (BAX) in both cortex and hippocampus, while hippocampal levels of sirtuin 1 (SIRT1) and B-cell lymphoma 2 (Bcl-2) increased. Treatment of animals with melatonin only after surgery (AT) resulted in similar effects, but to a lesser extent than in the PrevT group. In any case, melatonin acted as a valuable therapeutic agent protecting aged animals from the harmful effects of cerebral infarction.


Item Type:Article
Uncontrolled Keywords:aging; brain; ischemia; melatonin; middle cerebral artery blockade
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Physiology
ID Code:65879
Deposited On:10 Jun 2021 14:40
Last Modified:10 Jun 2021 15:38

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