Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease

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Ceprián Costoso, María and Fulton, Daniel (2019) Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease. International Journal of Molecular Sciences, 20 (10). p. 2450. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20102450




Abstract

Glia form a central component of the nervous system whose varied activities sustain an environment that is optimised for healthy development and neuronal function. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA)-type glutamate receptors (AMPAR) are a central mediator of glutamatergic excitatory synaptic transmission, yet they are also expressed in a wide range of glial cells where they influence a variety of important cellular functions. AMPAR enable glial cells to sense the activity of neighbouring axons and synapses, and as such many aspects of glial cell development and function are influenced by the activity of neural circuits. However, these AMPAR also render glia sensitive to elevations of the extracellular concentration of glutamate, which are associated with a broad range of pathological conditions. Excessive activation of AMPAR under these conditions may induce excitotoxic injury in glial cells, and trigger pathophysiological responses threatening other neural cells and amplifying ongoing disease processes. The aim of this review is to gather information on AMPAR function from across the broad diversity of glial cells, identify their contribution to pathophysiological processes, and highlight new areas of research whose progress may increase our understanding of nervous system dysfunction and disease.


Item Type:Article
Uncontrolled Keywords:glia; AMPA receptor; astrocyte; microglia; glutamate; excitotoxicity; inflammation; hypoxia; ischemia; multiple sclerosis; neurodegeneration
Subjects:Medical sciences > Medicine > Medical microbiology
ID Code:65881
Deposited On:10 Jun 2021 14:34
Last Modified:10 Jun 2021 15:39

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